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M9490681.TXT
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1994-09-24
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34 lines
Document 0681
DOCN M9490681
TI [Progressive multifocal leukoencephalopathy and AIDS. Response to
cytarabine]
DT 9411
AU Hervas Laguna MJ; Nieto Rodriguez JA; Geijo Martinez MP; Ruiz Ribo MD;
Borregon S; Servicio de Medicina Interna, Hospital Virgen de la Luz.,
Cuenca.
SO An Med Interna. 1994 May;11(5):241-3. Unique Identifier : AIDSLINE
MED/94339280
AB PML affects 4% of patients with AIDS and there is no effective
treatment. Five cases of PML-AIDS have been described, showing clinical
and radiological improvement after treatment with C-ara. We describe the
case of a 33-year-old woman, addict to heroin, her clinical record
including VIH infection, pneumonia by P. carinii, milliary tuberculosis,
infection by virus B and C and treatment with AZT and tuberculostatics
since January, 1992. In May, she began to develop a cerebellar syndrome.
Images obtained with nuclear magnetic resonance were typical of PML.
Subsequently, treatment with C-ara (2 mg/kg/day IV during 5 days each
4-6 weeks) was begun. From the third month of treatment on, the patient
showed a clinical improvement and as of the sixth month, the affected
areas of white substance were reduced in size. In addition, CD4
improved. Although in this patient a positive effect was observed after
treatment with C-area, it should be verified in a controlled clinical
trial.
DE Adult AIDS-Related Opportunistic Infections/*DRUG THERAPY Case Report
Cytarabine/*THERAPEUTIC USE English Abstract Female Human
Leukoencephalopathy, Progressive Multifocal/*DRUG THERAPY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).